Home > Uncategorized > Controlled Release Metoprolol in Moderate to Severe Aortic Regurgitation

Controlled Release Metoprolol in Moderate to Severe Aortic Regurgitation

Broch et al report a randomized placebo controlled clinical trial of use of controlled release metoprolol  in patients with moderate to severe aortic regurgitation. The primary end-point was change in LV volumes assessed by serial cardiac MRI (and echocardiography: 6 month interval). The study was neutral. Secondary end-points suggested the treatment was safe (if concomitant indication for beta-blockers). It is noteworthy that the beta-blocker group higher NT-pro BNP. The authors speculate with respect to changes in ejection fraction (increase) v elevated BP.

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