Home > Uncategorized > Events Rates: Paroxysmal versus Persistent/Permanent AF. Insights from ENGAGE AF-TIMI 48

Events Rates: Paroxysmal versus Persistent/Permanent AF. Insights from ENGAGE AF-TIMI 48

Link et al report on the relationship between types of atrial fibrillation and outcomes in the ENGAGE AF TIMI 48 trial.

Abstract

Background

Whether the pattern of atrial fibrillation (AF) modifies the risk/benefit of anticoagulation is controversial. In ENGAGE AF-TIMI 48 trial (Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation– Thrombolysis in Myocardial Infarction 48), the factor Xa inhibitor edoxaban was noninferior to warfarin in preventing stroke or systemic embolic events and significantly reduced bleeding and cardiovascular mortality. However, detailed
analyses by AF pattern have not been reported.

Methods and Results

The 21 105 patients were categorized as having paroxysmal (

Conclusions

In ENGAGE AF-TIMI 48 trial, patients with paroxysmal AF suffered fewer thromboembolic events and deaths compared with those with persistent and permanent AF. The efficacy and safety profile of edoxaban as compared with warfarin was consistent across the 3 patterns of AF.

 

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